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20 Best-Selling Face Serums Broken Down by Cost Per Wear

Shopping for skincare is one of our absolute favorite pastimes—face serums, especially. They're one of the most strategic ways to enhance and customize our glow routine, effortlessly stacking and boosting the benefits we're already getting from our other staples like cleansers, creams, and masks. While shopping for pretty much any kind of serum gets our adrenaline pumping in the best way possible, we're especially exhilarated by best-selling face serums everyone and their mother is dying to get their complexion on.

Call us superficial, but we want something that's effective and results-driven, yes, but also covetable and brimming with holy-grail potential, which is where one of our all-time favorite beauty retailers, Dermstore, comes in. Boasting every type of beauty product imaginable (from hair to skincare to makeup), it's one of our first stops whenever we're in the market for top-quality new finds that are high on the industry's most-wanted list. The store carries everything from professional-strength formulas you'll likely only find at the dermatologist's office to niche spa, specialty, and natural beauty brands hailing from all around the world. Not surprisingly, it has an amazing collection of best-selling face serums as well.

Since everyone has different goals and concerns when it comes to the wellness of both our skin and bank account, we decided to dissect the top 20 best-selling face serums you can buy on Dermstore's website right now—breaking each formula down by its benefits, ingredients, and cost per wear. (We're guestimating each small bottle will last roughly three months but realize this might fluctuate.) Ahead, 20 best-selling face serums everyone wants from Dermstore and how much they'll cost you per application. (We're starting our countdown with the retailer's 20th bestseller, so make sure to scroll all the way down to see which holy grail serum took the number one spot!)

Treats: fine lines and wrinkles, loss of firmness, dullness, environmental damage. Key ingredients: peptides, vitamin E, antioxidants. Cost per wear: $70 ÷ 90 wears (three months, once daily in the evening) = $0.78 per wear
Treats: dryness, dullness, fine lines and wrinkles, environmental damage. Key ingredients: hyaluronic acid, ceramides, niacinamide. Cost per wear: $115 ÷ 180 wears (three months, twice daily) = $0.64 per wear
Treats: loss of firmness, fine lines and wrinkles, environmental damage, pH disruption. Key ingredients: bamboo, coconut oil, coconut water, plant stem cells, natural retinol alternative complex. Cost per wear: $62 ÷ 180 wears (three months, twice daily) = $0.34 per wear
Treats: dullness, dehydration, cell build-up and congestion, loss of firmness and plumpness, fine lines and wrinkles, environmental damage, uneven skin texture. Key ingredients: strawberry, rhubarb, hyaluronic acid (derived from marshmallow plant extract), honey, aloe vera. Cost per wear: $48 ÷ 180 wears (three months, twice daily) = $0.27 per wear
Treats: pre-mature signs of aging, hyperpigmentation, loss of firmness, fine lines and wrinkles, environmental damage, collagen depletion, dullness. Key ingredients: niacinamide, amino acids, algae extract, peptides. Cost per wear: $112 ÷ 180 wears (three months, twice daily) = $0.62 per wear
Treats: uneven skin tone, uneven skin texture, loss of firmness, fine lines and wrinkles, environmental damage, dullness. Key ingredients: vitamin C, vitamin E, antioxidants. Cost per wear: $102 ÷ 90 wears (three months, once daily in the morning) = $1.13 per wear
Treats: hyperpigmentation, dryness, environmental damage, dullness and congestion, loss of firmness, uneven skin tone, fine lines and wrinkles. Key ingredients: kombucha blend, amino acids, hyaluronic acid, glycolic acid. Cost per wear: $82 ÷ 180 wears (three months, twice daily) = $0.45 per wear
Treats: redness and inflammation, environmental damage, hyperpigmentation, large pores, dullness, acne. Key ingredients: hyaluronic acid, herbal extracts. Cost per wear: $67 ÷ 180 wears (three months, twice daily) = $0.37 per wear
Treats: hyperpigmentation, large pores, fine lines and wrinkles, loss of firmness, environmental damage, acne and congestion, uneven skin texture, collagen depletion. Key ingredients: lactic acid, licorice extract, aloe vera, lemongrass. Cost per wear: $122 ÷ 90 wears (three months, once daily) = $1.35 per wear
Treats: discoloration, hyperpigmentation, dullness, and a healthier skin barrier. Key ingredients: tranexamic acid, niacinamide, phenylethyl resorcinol, marine extract blend, phytic acid. Cost per wear: $154 ÷ 180 wears (three months, twice daily) = $0.86 per wear
Treats: large pores, milia, inflammation/hyperpigmentation, uneven skin texture, dullness, cell regeneration, and environmental damage. Key ingredients: growth factors, glycolic acid, salicylic acid, AHA acids. Cost per wear: $179 ÷ 180 wears (three months, twice daily) = $0.99 per wear
Treats: environmental damage, accelerated signs of aging, hyperpigmentation, loss of firmness. Key ingredients: resveratrol, vitamin E, niacinamide, caffeine. Cost per wear: $153 ÷ 90 wears (three months, once daily in the evening) = $1.70 per wear
Treats: hyperpigmentation, dullness, environmental damage, acne, scarring, melasma. Key ingredients: tranexamic acid, kojic acid, vitamin B3. Cost per wear: $98 ÷ 180 wears (three months, twice daily) = $0.54 per wear
Treats: dullness, acne, uneven skin texture, fine lines and wrinkles, hyperpigmentation, environmental damage, loss of firmness. Key ingredients: sugar cane extract, salicylic acid, mushroom extract. Cost per wear: $138 ÷ 90 wears (three months, once daily) = $1.53 per wear
Treats: dehydration, dullness, fine lines and wrinkles, uneven skin texture, and loss of firmness. Key ingredients: hyaluronic acid, vitamin B5. Cost per wear: $83 ÷ 180 wears (three months, twice daily) = $0.46 per wear
Treats: hyperpigmentation, discoloration, acne, fine lines, uneven skin tone, environmental damage. Key ingredients: phloretin, vitamin C, ferulic acid. Cost per wear: $166 ÷ 90 wears (three months, once in the morning) = $1.84 per wear
Treats: environmental damage, hyperpigmentation, dryness, collagen depletion. Key ingredients: vitamin C, hyaluronic acid, antioxidants. Cost per wear: $127 ÷ 90 wears (three months, once in the morning) = $1.41 per wear
Treats: dryness, uneven skin texture, loss of firmness, lines, and wrinkles. Key ingredients: proxylane, hyaluronic acid, and a strategic blend of licorice root and purple rice extract. Cost per wear: $100 ÷ 180 wears (three months, twice daily) = $0.55 per wear
Treats: dryness, cell regeneration, hyperpigmentation, environmental damage, loss of firmness, lines, and wrinkles. Key ingredients: TNS (growth factor), peptides, and antioxidants from green tea, CoQ10, and EGT. Cost per wear: $281 ÷ 180 wears (three months, twice daily) = $1.56 per wear
Treats: lines, wrinkles, dullness, dryness, hyperpigmentation, loss of firmness, and environmental damage. Key ingredients: vitamin C, vitamin E, and ferulic acid. Cost per wear: $166 ÷ 90 wears (three months, once daily) = $1.84 per wear. Next up, 28 Holy Grail Skincare Products That Cost Less Than $5 Per Wear. This article was published at an earlier date and has been updated.


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